E1271

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Application	Reagent for the covalent modification of cysteine residues in proteins.
Biochem/physiol Actions	Augments currents from native M-channels in sympathetic neurons and acts as an opener for KCNQ2, KCNQ4 and KCNQ5 channels.
	Sulfhydryl alkylating agent that inactivates NADP-dependent isocitrate dehydrogenase and many endonucleases.

grade	SigmaUltra
assay	≥98% (HPLC)
total impurities	≤0.001% Phosphorus (P)
	≤0.1% Insoluble matter
ign. residue	≤0.1%
bp	210 °C(lit.)
mp	43-46 °C(lit.)
solubility	95% ethanol: 50 mg/mL colorless to faint yellow, clear to slightly hazy
anion traces	chloride (Cl^-): ≤0.05%
	sulfate (SO₄^2-): ≤0.05%
cation traces	Al: ≤0.0005%
	Ca: ≤0.0005%
	Cu: ≤0.0005%
	Fe: ≤0.0005%
	K: ≤0.005%
	Mg: ≤0.0005%
	Na: ≤0.005%
	Pb: ≤0.001%
	Zn: ≤0.0005%
Gene Information	human ... SLC6A3(6531), SLC6A4(6532)
storage temp.	2-8°C

Personal Protective Equipment	Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges
Hazard Codes	T+
Risk Statements	21-28-34-43
Safety Statements	26-28-36/37/39-45
RIDADR	UN2928 6.1/PG 2
WGK Germany	3
RTECS	UX9625000
Flash Point(F)	163.4 °F
Flash Point(C)	73 °C

reference	Riordan, J.F. and Vallee, B.L., Reagent for the modification of sulfhydryl groups in proteins. Meth. Enzymol. 25, 449-456, (1972)
	W.J.H. Van Berkel et al. Eur. J. Biochem. 145, 245, (1984)
Merck	Merck 13,3855
Beilstein	Beil. 21,V,10,6
	Aldrich MSDS 1, 918:D / Corp MSDS 1 (1), 1631:C / FT-IR 1 (1), 797:D / FT-IR 2 (1), 1354:B / FT-NMR 1 (1), 1304:A / IR-Spectra (2), 419:G / IR-Spectra (3), 473:C / NMR-Reference 2 (1), 669:A / RegBook 1 (1), 935:B / Sax 6, 1726 / Sigma FT-IR 1 (2), 555:D / Structure Index 1, 145:B:6